Andryushkino, Argakhtakh, Chokurdakh, Nizhneyansk, Olenegorsk, Russkoye Ustye, Srednekolymsk, and Zyryanka are among the few towns in the area.

Except for a small section at the southern end the lowland region lies almost wholly north of the Polar Circle.

[3] These smaller lowland units are limited by residual ridges which break the generally flat relief, including the Kyundyulyun, Polousny Range, Ulakhan-Sis, Kondakov Plateau and Suor Uyata, as well as by isolated hills rising from the tundra, such as the Kisilyakh-Tas by the Alazeya.

[4] Continuous permafrost is prevalent in the East Siberian Lowlands, and permafrost-related formations such as alas thermokarst depressions and baydzharakh mounds are common throughout the region.

Moving further inland, the chilling effect of the cold sea declines, enabling the Siberian landmass to heat up summer temperatures.

The total reindeer population of the East Siberian Lowland, however, is small when compared with other areas, such as the Canadian Arctic.

[8] In the summer the wetlands are home to large populations of migratory birds, including the Siberian crane, Brent goose, Bewick's swan and the spectacled eider.