His father, noting his son's interest in acting, encouraged him to reply to a newspaper advertisement seeking "child actors".

[4] Bisson's first major role was in the 1984 CBC movie of the week Hockey Night, alongside Megan Follows and Rick Moranis.

[citation needed] He starred as FBI agent Jack Hudson in the PAX TV series Sue Thomas: F.B.Eye[5][6] and in the short-lived CBC drama Nothing Too Good for a Cowboy.

[citation needed] Bisson plays the lead in the CBC Television drama series Murdoch Mysteries[10] and made his directorial debut with the show's fourth-season episode "Buffalo Shuffle".

He is introduced in "Three Bedrooms, One Corpse" as a CIA agent Bartell who moves to town, falls in love with Teagarden, and later dates her.

[17][18] Bisson is married to Chantal Craig,[19][20] a former actress, model, Toronto Argonauts Cheerleader, and fitness instructor who currently works as a television content creator and writer.

Dominique Bisson had a part as Gloria Abercrombie in an episode of Murdoch Mysteries, season 2, entitled "Snakes and Ladders".