On the late evening of 26 November 2010, 13-year-old Italian schoolgirl Yara Gambirasio disappeared after being at the sports centre of her city, Brembate di Sopra, Lombardy, Italy, to bring a stereo for a gymnastics competition scheduled for the following weekend.

[1] The body, now decomposed, showed multiple deep cuts and a head wound, inflicted when the victim was still alive and not individually lethal.

Forensic scientists analyzed 22,000 DNA profiles from a trace found on Yara's underwear and leggings, eventually leading to the arrest of Massimo Bossetti, a local construction worker, in June 2014.

Bossetti pleaded not guilty to the abduction and killing,[4] arguing his DNA was either contaminated or fabricated, but police maintained the sample was of excellent quality.

Despite questions about the DNA evidence, Bossetti was sentenced to life imprisonment by the Corte d'Assise of Bergamo in July 2016,[4] with the verdict upheld on appeal and confirmed by the Court of Cassation in October 2018.

At 6:44 PM on 26 November 2010, Yara Gambirasio left the Brembate di Sopra, Italian sport center alone, but never reached her home 700 meters away.

Her family soon called the Carabinieri,[6] but despite a search involving hundreds of volunteers, her body was not found until 26 February 2011 in Chignolo d'Isola, 10 kilometers from Brembate.

The body showed multiple cuts, possibly made by a pointed object such as a nail or a knife, and a large wound on the head.

On 16 June 2014, an Italian bricklayer living and working in the area, Massimo Giuseppe Bossetti, was arrested and accused of being the murderer, mainly by virtue of his DNA matching "Ignoto 1"'s.

Bossetti consistently proclaimed his innocence, stating he suffered from nosebleeds and that someone had stolen his work tools, including a knife, an awl and a trowel, possibly blood-soiled, and that the DNA proof was fabricated, due to either excessive exposure to the weather or cross-contamination.

[citation needed] In 2024, Netflix released a documentary series, named The Yara Gambirasio Case: Beyond Reasonable Doubt, covering the abduction, trial and issues surrounding the DNA.