She is the younger daughter of American movie actress and dancer Rita Hayworth, and the third child of Prince Aly Khan, Pakistan's representative to the United Nations from February 1958 until his death in 1960.

Her paternal half-brother was Prince Karim al-Husayni, the fourth Aga Khan.

Khan was born at Clinique de Montchoisi in Lausanne, Switzerland;[1] she spent her early life with her mother and her maternal half-sister, Rebecca Welles Manning (1944–2004), daughter of Hayworth's marriage to Orson Welles.

Yasmin, then only three years old, played about the court while the case was being heard, finally climbing on to the judge's lap.

[7] She is also the president of Alzheimer's Disease International, a National Council Member of the Salk Institute, and a spokesperson for the Boston University School of Medicine, Board of Visitors.