He served as archimandrite of a monastery in the Pinsk region from 1595 to 1599, and of Kyiv Pechersk Lavra from 1599 until his death.
He established a hospital for the poor, a printing house, and the Radomysl paper mill.
Pletenetsky attracted a group of notable church and cultural figures at the monastery, including Pamva Berynda, Stepan Berynda, Job Boretsky (later Metropolitan of Kiev, Galicia and all Rus'), Havrylo Dorofeievych, Zacharias Kopystensky, Taras Zemka, and Lavrentij Zizanij.
In 1620 Reverend Elisius played a key role in petitioning to Patriarch of Jerusalem Theophanes III who stopped in Kyiv in re-establishing of new Eastern Orthodox bishop hierarchy by blessing a new metropolitan bishop Job Boretsky.
On 17 February 1625 hieroschemamonk Euthymius was buried in the newly restored Holy Dormition temple of the Kyiv Cave Monastery next to the tombstone of the Great Duke of Lithuania Skirgaila and Duchess Eupraxia of Kiev, a sister of Volodymyr Monomakh.