It is located in the west of the krai and borders with Turukhansky and Evenkiysky Districts in the north, Severo-Yeniseysky and Motyginsky Districts in the east, Kazachinsky District in the southeast, Pirovsky, Birilyussky, and Tyukhtetsky Districts in the southwest, Tomsk Oblast in the west, and with Khanty–Mansi Autonomous Okrug in the northwest.

The area of the district is 106,300 square kilometers (41,000 sq mi).

[2] Within the framework of administrative divisions, Yeniseysky District is one of the forty-three in the krai.

[1] The town of Yeniseysk serves as its administrative center, despite being incorporated separately as a krai town[1]—an administrative unit with the status equal to that of the districts.

[11] The district is divided into one urban-type settlement (Podtyosovo) and twenty-five selsoviets.