[citation needed] Canó did not play in a game in 2020 due to the cancellation of the minor league season because of the COVID-19 pandemic.

[1] He spent the 2021 season with the Double-A Wichita Wind Surge and Triple-A St. Paul Saints, pitching to a cumulative 5–3 record and 3.23 ERA with 86 strikeouts and 5 saves in 69.2 innings of work.

[4] Canó made three appearances for the Orioles, but struggled immensely, allowing 9 runs on 9 hits with 7 strikeouts in 4.1 innings pitched.

He retired the first 24 batters he faced without allowing a base runner to begin the season, tying an Orioles record held by Fred Holdsworth.

[8] Canó was announced as part of FEPCUBE's "Patria y Vida" team of expatriate Cuban ballplayers participating in the inaugural Intercontinental Series in Barranquilla, Colombia.