He entered the world of political cartoons in 1960, drawing for Janayugom, the Malayalam daily of the Communist Party of India.

[4] He worked there for three years, drawing a pocket cartoon with the character Kittumman, after which he joined Shankar's Weekly in Delhi.

[4] He joined the Malayala Manorama group in 1985 as staff cartoonist, running cartoon columns in the paper and The Week magazine.

[5] Yesudasan died in Kochi on 6 October 2021 at the age of 83 from a heart attack caused by COVID-19 during the COVID-19 pandemic in India.

[8][9][10] He is a member of the Malankara Orthodox Syrian Church and his funeral took place at St. Mary Chapel in Chittoor.