[1] The first recorded settlement in the area, called Kerkinitis (Κερκινίτις), was built by Greek colonists around 500 BCE.

Along with the rest of the Crimea, Kerkinitis formed part of the dominions of King Mithridates VI Eupator (r. 120–63 BCE).

In this connection, a complex of two prayer houses was built under the supervision of the Rabovich brothers, in which the Renaissance and Muslim architectural styles entwined in a most unusual manner.

Polish poet Adam Mickiewicz visited the town in 1825 and wrote one of his Crimean Sonnets here; it was later translated into Russian by Mikhail Lermontov.

It became a garrison of Ottoman troops later during the war and was the site of the Battle of Eupatoria in February 1855, which was the largest military clash in the Crimean theatre outside the Sevastopol area.

Natural factors at Yevpatoria created beneficial conditions for the treatment of osteoarticular tuberculosis and other children's diseases; in 1933, at a scientific conference in Yalta, it was agreed that among Soviet resort towns for the organization of children's resorts, most people approved Yevpatoria.

[8] In 2014 due to the military operation of the Russian Armed forces, the city of Yevpatoria was occupied by Russia along with the entire Crimean peninsula.

The UN General Assembly condemned the Russian operation and considered the annexation the temporary occupation of part of the territory of Ukraine—the Autonomous Republic of Crimea and the City of Sevastopol.

These resorts belong to a vast area with curative facilities where the main health-improving factors are the sunshine and sea, air and sand, brine and mud of the salt lakes, as well as the mineral water of the hot springs.

The curative qualities of the local mud was witnessed by the manuscripts of Pliny the Elder, a Roman scholar (c. 80 BC).