Ebony Maw (voiced and portrayed via motion capture by Tom Vaughan-Lawlor) is an adopted son of Thanos and member of the Black Order who is killed in space after being defeated by Tony Stark and Peter Parker.
Karli Morgenthau (portrayed by Erin Kellyman) is the teenage leader of the anti-nationalist terrorist group the Flag Smashers, who were made Super Soldiers with the help of the Power Broker (Sharon Carter) and use violent tactics such as bombings to achieve open borders for refugees in the Baltic states.
The effects of the herb caused her and the rest of Yucatán's people to develop blue skin and grow gills that restricted their ability to breathe air on the surface, thus forcing them to relocate underwater and establish Talokan as a new civilization.
The herb additionally caused her son to undergo a mutation at birth, which gave him pointed ears, winged ankles enabling him to fly, and the ability to breathe oxygen and water simultaneously.
Cassandra Nova (portrayed by Emma Corrin) is a mutant with telekinetic and telepathic powers, who is the twin sister of Charles Xavier with other-worldly origins and was banished to the Void by the Time Variance Authority (TVA).
[60] Phastos (portrayed by Brian Tyree Henry) is an Eternal and an intelligent cosmic-powered inventor who helps humanity progress technologically behind the scenes before abandoning them to live in exile following the bombing of Hiroshima.
In another alternate universe, Pym dresses in the Yellowjacket armor and murders prospective Avengers Tony Stark, Thor, Clint Barton, Bruce Banner, and Natasha Romanoff as revenge on Nick Fury for Hope's death.
In another alternate universe, Pym, still serving as Ant-Man, is recruited by Howard Stark and Peggy Carter in 1988 to join a response team to address the threat posed by Ego and his son Peter Quill.
In the alternate universe designated as Earth-838, Maria takes up the mantle of Captain Marvel instead of Danvers, serving as a member of the Illuminati until she is killed by Wanda Maximoff who dropped a statue on her after having her powers absorbed.
When the Dweller-in-Darkness escapes his seal, Razor Fist orders the Ten Rings into working with the Ta Lo villagers to help battle the Dweller and his minions as he replaces his blade with one made of dragon scales.
Five years later, Irani Rael made a deal with Ronan to surrender Xandar to him in exchange for being allowed to continue ruling it, but she is foiled by Thanos's surviving adopted daughter Nebula.
Thaddeus E. "Thunderbolt" Ross (initially portrayed by William Hurt and later by Harrison Ford), also known as Red Hulk, is a United States general who is responsible for reviving the super-soldier project so he can create a weapon.
After being exposed by Rogers as a Hydra operative, Rumlow comes into conflict with Sharon Carter and Sam Wilson in the Triskelion until a Helicarrier crashes into it, leaving him with severe burns and facial scars.
Eric Savin (portrayed by James Badge Dale) is a former Lieutenant Colonel and Aldrich Killian's right-hand man who undergoes the Extremis treatment to enhance his combat skills and give himself various fire-based powers as well as a regenerative healing factor.
Johann Schmidt (portrayed initially by Hugo Weaving and subsequently by Ross Marquand), also known as the Red Skull, is the head of Hydra, the Nazi science division during World War II.
In a deleted scene, a grown-up Morgan (portrayed by Katherine Langford) has a conversation with her father in the Soul World after he sacrifices himself to save the universe by using the Infinity Stones to defeat Thanos.
In 1992, T'Chaka learned his brother N'Jobu was plotting acts of open insurrection with plans to have Wakanda take a more aggressive foreign policy to fight the social injustice he witnessed in his assigned country.
While visiting the ancestor lands, T'Challa tells T'Chaka and the previous Black Panthers before him that he will lead Wakanda in a manner differently to them for the purpose of correcting his father's past mistakes.
[9]: 2 Ted (motion-captured by Carey Jones, vocal effects provided by Jeffrey Ford), also known as Man-Thing, is a swamp monster and friend of Jack Russell who was captured by the Bloodstone family for their hunt.
[128] Taneleer Tivan (portrayed by Benicio del Toro), also known as the Collector, is the renowned keeper of the largest collection of interstellar fauna, relics and species in the galaxy, operating from the Knowhere port installation.
In 2012, he chooses to become a criminal after the creation of the Department of Damage Control, a joint venture between the federal government and Tony Stark following the Battle of New York, which results in Toomes's company being run out of business.
With his associates, Phineas Mason, Herman Schultz, Jackson Brice, and Randy Vale, he begins an illegal arms-dealing business that reverse-engineers and weaponizes Chitauri technology that they have scavenged and salvaged, and sells it on the black market.
Ultron (portrayed by James Spader) is an artificial intelligence conceived and designed by Tony Stark and Bruce Banner as the head of a peacekeeping program, who subsequently takes the form of a sentient android overwhelmed with a god complex, determined to pacify the Earth by eradicating humanity.
After the Watcher forms the Guardians of the Multiverse, Ultron becomes aware of and battles the team, but fails to defeat them due to Stephen Strange Supreme's immense power and protection spells.
Xu Wenwu (portrayed by Tony Leung) is the legendary founder and supreme leader of the Ten Rings terrorist organization, and is the father of Shang-Chi in place of Fu Manchu / Zheng Zu from Marvel Comics.
Riri Williams (portrayed by Dominique Thorne), also known as Ironheart, is an MIT student and genius inventor from Chicago who creates a suit of armor that rivals the one built by Tony Stark / Iron Man, and whose vibranium detector is stolen by the CIA, leading to her being hunted down by Talokan and Wakanda.
W'Kabi loses faith in T'Challa when he fails to capture Ulysses Klaue (who had killed his parents decades earlier while stealing vibranium), and supports N'Jadaka when he subsequently takes the throne.
[103] Alice Wu-Gulliver (portrayed by Ali Ahn) is an ex-police officer and security guard whose mother Lorna was a famous singer and witch before dying in a hotel fire while on tour.
Refinery29 reviewer Leah Marilla Thomas praised this adaptation of Shang-Chi's mother for the "mythical (and devastatinlgy romantic) backstory", which makes her a "real character" as compared to the brief appearances of the earlier comics version.
Despite his initial failure to overwrite Ultron's A.I., Zola acquires the android's body in his second attempt and battles Killmonger for the Infinity Stones before the two are trapped in a pocket dimension by Stephen Strange Supreme and the Watcher.