Yitzhak Rafael (Hebrew: יצחק רפאל, 5 July 1914 – 3 August 1999) was an Israeli politician.

Rafael was born in Sasiv in Galicia in 1914 at a time when the town was part of Austria-Hungary (now Ukraine), and attended high school in Poland.

Rafael was married to Geula, daughter of Yehuda Leib Maimon, Israel's first Minister of Religious Affairs.

However, when Yitzhak Rabin formed a new government in June 1974 following Meir's resignation, the NRP were not included in the coalition and Rafael left the cabinet.

In the same year he lost the party leadership when Zevulun Hammer and Yosef Burg combined forces to oust him.