Yizhen county was renamed Yizheng in 1723, because the homophone "zhen(禛)" as a part of the Yongzheng Emperor's Chinese name was deemed to be ineffable.

On the northern bank of Yangzhou, Yizheng is situated in the north of Jiangsu, and the Yangtze River lies in its southern territory.

The city borders Luhe District of Nanjing on west, the urban area of Yangzhou on east and Tianchang of Anhui Province on north.

Two major bodies of water, the Yangtze River and the Grand Canal, run through Yizheng from west to east and from north to south, respectively, dividing the city into four fractions.

[5] G40 Shanghai–Xi'an Expressway China National Highway 328 The passengers service of Yizheng Station astride the Nanjing–Qidong railway was suspended since July 1, 2013.