[4] When she was starting out as an artist, she participated as a staff member of the First World Festival of Black Arts in Dakar in 1966.
[2][5] She has worked on public commissions for the offices of the Organisation of African Unity in Ethiopia and Léopold Sédar Senghor International Airport in Dakar, among others.
[2] Sèye works in mixed media, combining oil painting with embellishments, most notably cowrie shells.
[2] She herself was offered a spot at the École Nationale des Beaux Arts (Senegal), which would have made her the first woman student there, but she turned it down due to family and career obligations.
[4] Her position as a successful female artist in the Dakar art world in this period was unique, and she has been described as Senegal's first woman painter.
[2][9] Decades later, in 2000, she collaborated again with Sembène, playing the lead role in Faat Kiné under the stage name Venus Seye.