Married to English singer-songwriter and the Beatles member John Lennon until his murder in 1980, she has contributed several B-sides to his singles from late 1960s to the 1980s.

Similar moderate success was achieved with her follow-up records Fly (1971) and Approximately Infinite Universe (1973).

Simultaneously, she released several collaborative albums with Lennon, starting with their Unfinished Music series spawning Two Virgins (1968) and Life with the Lions (1969).

Starting with 2001, the singer began re-releasing several remixes of her or Lennon's old material as singles, alongside new original songs.

She has since then reached number one 13 times on Billboard's Dance Club Songs component chart, the last one being in 2017 with "Hell in Paradise 2016".