It is a bypass that travels from the southwestern corner of the city in Totsuka-ku northeast to Kanagawa-ku.

The expressway has another major junction with the Yokohama Yokosuka Road in Hodogaya-ku before crossing into Totsuka-ku.

In Totsuka-ku, the expressway has a few more interchanges before transitioning back to a highway with signaled intersections.

After this transition, the road eventually ends at an intersection with the main line of National Route 1.

[2] The route that would eventually become the free section of the Yokohama Shindō was established in 1948 during the Occupation of Japan as a bypass of the older Tōkaidō.