At the age of 16, Yoo In-na joined an entertainment agency as an apprentice singer in 1998, and had nearly become part of a girl group.

[10] She also sang for the soundtrack of her 2011 film My Black Mini Dress alongside her castmates Yoon Eun-hye, Park Han-byul, and Cha Ye-ryun.

[13][14][15][16] At a June 7, 2012, fan meeting to mark the end of Queen and I, Ji Hyun-woo made a surprise public declaration that he was in love with co-star Yoo.

[25][26] Speculation about their relationship status ended on June 17, when gossip website Sportsseoul.com photographed the couple together on a midnight date at a park in Bundang, Gyeonggi, where Yoo lives.

[32][33][34] On February 9, 2023, Yoo donated 30 million won to help in 2023 Turkey–Syria earthquake through Hope Bridge National Disaster Relief Association.