His notable works include the films Re-encounter (2011), Architecture 101 (2012), A Werewolf Boy (2012), Whistle Blower (2014), and Love, Lies (2016), as well as the television series Reply 1994 (2013), Dr.

[1][2] After appearing in Oldboy, Yoo spent a solid amount of time in preparation before becoming a fully-fledged actor, including entering the Department of Film Arts at Sejong University and serving in the military.

[4] Yoo took on supporting roles on television, such as the haughty student body president in the horror series Soul and more appealing characters in medical drama Midnight Hospital and Tasty Life.

[16] Following his breakout year, he was cast in two high-profile films in 2014: Whistle Blower about infamous biotech researcher Hwang Woo-suk, and Joseon-set period drama The Royal Tailor.

[20][21] In 2015, Yoo was cast in his first leading role on network television as a chef and restaurateur in the romantic comedy series Warm and Cozy, written by the Hong sisters and set on Jeju Island.

[30] In 2020, Yoo starred in the critically acclaimed and hit medical drama Hospital Playlist, playing Ahn Jeong-won, an assistant professor of pediatric surgery[31] and reprised his role in season 2 in 2021.