[7] In 1999, Kamdzhalov began to study conducting at the Sofia Conservatory under Vassil Kazandjiev and continued at the Hanns Eisler University of Music in Berlin under Christian Ehwald, simultaneously completing training as a choir conductor.

[1][8] He was selected to work over an extended period with the Philharmonia and London Philharmonic Orchestras, which led to his collaboration with well-established conducting mentors including Lorin Maazel, Vladimir Jurowski and Esa Pekka Salonen.

[25][6] In 2018 he led the Genesis Orchestra for a concert in National Palace of Culture, Bulgaria, featuring Lisa Gerrard in Górecki's Symphony No.3 and Vehadi improvisation on music by Beinsa Duno, later released internationally on CD.

[4] In 2014, Kamdzhalov assumed the roles of artistic director and Principal Conductor as well as participant in the Music Laboratory for the Human Self, a conceptual platform unfolded in three choral formats: Choir, Ensemble and Bulgaria Sings.

[30] In the spring of 2024, the "Yordan Kamdzhalov" launched the Academy for the Human Self - an interdisciplinary educational center consisting of training on Science (mathematics and physics), Art (theory of music, piano, violin, percussion instruments and dance) and Sport (chess and table tennis).

[24][32][33] In April 2024, Kamdzhalov announced the latest concert-spectacle with the Genesis Orchestra, Music Laboratory (Choir and Ensemble), Eastern Quartet (Switzerland) and Sofi Marinova, titled Mystery and Freedom.

[34] Recognizing the potential of Bulgarian music and talent to enrich global culture, Kamdzhalov considers the expansion of his projects in Bulgaria in recent years a paramount endeavor.