They are known for their juxtaposition of "passionate" and "upbeat" production and instrumentation fused with heavier lyrical content, which often explore ideas such as love and human emotion and draw from works of literature including Masuji Ibuse and Jules Verne.

[3] The name "Yorushika" is taken from a lyric in their song "The Clouds and the Ghost"; "yoru shika mō nemurezu ni" (夜しかもう眠れずに, meaning "I can't sleep at night").

[5] Prior to the formation of Yorushika, N-buna already had a sizeable following on Niconico, a Japanese video hosting website, first releasing vocaloid music on the platform in 2012.

[1] Additionally, the song "Just a Sunny Day for You" (ただ君に晴れ, Tada Kimi ni Hare) also became popular in video app TikTok.

[16] In 2022, they provided the theme song "Left-Right Confusion" (左右盲, Sayūmō) for the movie Even If This Love Disappears from the World Tonight and The Fruits of the Earth (チノカテ, Chinokate) for the Japanese TV drama "Renovation like Magic" (魔法のリノベ, Mahō no Rinobe).

In 2025, Yorushika contributed the song "Snake" (へび, Hebi) as the second ending theme for the anime Orb: On the Movements of the Earth.