It has been serialized since January 2003 in the monthly magazine Dengeki Daioh by ASCII Media Works, formerly MediaWorks, and has since been collected into 15 tankōbon volumes.

It depicts the everyday adventures of a young girl named Yotsuba as she learns about the world around her, guided by her adoptive father, their neighbors, and their friends.

is centered on Yotsuba Koiwai, a five-year-old[18] girl who is energetic, cheerful, curious, odd, and quirky—so much so that even her own father calls her unusual.

She is also initially ignorant about many things that a child her age would be expected to know—among them doorbells, escalators, air conditioners, and even playground swings.

[12] In addition, the series is licensed in Malaysia in both English and Malay by Kadokawa Gempak Starz,[5][22] in France by Kurokawa,[23] in Spain by Norma Editorial,[24] in Germany by Tokyopop Germany,[25] in Italy by Dynit,[26] in Sweden by B. Wahlström,[27] in Finland by Punainen jättiläinen,[28] in Korea by Daiwon C.I.,[29] in Taiwan by Kadokawa Media,[30] in Russia by Palma Press[31] in Vietnam by TVM Comics,[32] in Poland by Kotori,[33] in Indonesia by Elex Media Komputindo[34] and in Thailand by NED Comics.

[37] The 2005 edition of the monthly calendar featured pictures of Yotsuba playing with animals such as lions, zebras, and kangaroos.

The 2006, 2007, 2008, and 2010 editions feature photographs altered to include Yotsuba doing such things as playing with other children or reaching for a balloon.

Both albums are composed by Masaki Kurihara and performed by the Kuricorder Pops Orchestra, who also worked together on the Azumanga Daioh soundtrack.

[45] An anime spin-off based on cat versions of Azuma's character Danbo titled Nyanbo!

In an entry posted on his website on 15 May 2005, Azuma said there were no plans for it to be animated;[48] he reiterated this on 5 December 2008, claiming that the stories and style of Yotsuba&!

is drawn not in the vertical four-panel strips of Azuma's earlier series, Azumanga Daioh, but in a full-page format, giving him more artistic scope.

[54][55] Azuma is also praised for his joyous tone,[52][56] slice-of-life storytelling,[4] comedic writing,[1][2][3] and eccentric yet realistic characters, especially Yotsuba herself.

[6][7][50][56][57] The Comics Reporter described the series as "read[ing] like a love letter to the way kids can be at the age of 2–5,"[58] and a reviewer at Anime News Network compared Azuma's ability to capture "the wonder of childhood" to Bill Watterson's in Calvin and Hobbes.

[59] Nicholas Penedo of Animeland said "with Yotsuba, we find ourselves plunged into the wonderful world of childhood," calling the French edition of volume eight, "A beautiful manga for children and adults.

"[60] BD Gest praised Azuma's skill in making distinct secondary characters, calling them "immediately recognisable", and saying that they each spice up the story in their own ways.

[61] However, Azuma has been criticized for creating characters that are "too clean, too perfectly functional",[2] for overusing "outrageous expressions and reactions",[50] and for dragging out jokes too long.

[66] The first five volumes of the English translation were each among the top 100 selling graphic novels in the United States in the month of release.

received an Excellence Award for Manga at the 2006 Japan Media Arts Festival, where the jury citation praised the vivid characters and gentle atmosphere.

won the Grand Prize at the 20th Osamu Tezuka Culture Awards, sharing it with Kei Ichinoseki's Hanagami Sharaku.

[79][80] Another exhibition of Yotsuba&!, featuring new original artwork by Kiyohiko Azuma, was held at the Osamu Tezuka Manga Museum in Takarazuka, Hyōgo Prefecture between June and October 2020.