The series follows Jimmy (Chris Geere), a self-involved writer, and Gretchen (Aya Cash), a self-destructive PR executive, as they attempt a relationship, along with their friends Edgar (Desmin Borges) and Lindsay (Kether Donohue).

Gretchen is the publicist for a rap trio and lives in a chaotic apartment, while Jimmy, a writer, can support himself in upscale Silver Lake and drive a BMW despite having published only one novel, written during his post-breakup depression, that has sold little and been remaindered at the local bookstore.

He supports himself by writing for glossy magazines, in addition to the tiny royalty checks that occasionally arrive in his mailbox.

In a parallel story, Lindsay is married to affluent, conventional Paul, who is decent but plain with somewhat nerdy interests like astronomy, beer-brewing, and cycling.

For her part, Becca is no happier with her husband Vernon, an immature man who is only interested in hanging out with friends in his man-cave, drinking while watching sports and videos.

Jimmy also has a roommate named Edgar, an Iraq War veteran suffering from post-traumatic stress disorder (PTSD), living in his house.

[19] For season 3, a replica of the interior of the house was constructed on a sound stage, slightly enlarged to improve camera access.

The site's consensus reads, "You're the Worst uses clever writing – and its stars' palpable chemistry – to balance comedic elements against its realistically pessimistic tone.

The site's critical consensus reads, "Expertly balancing character growth against edgy humor, season two of You're the Worst elevates the show's excellent writing and talented cast to a new level.

The site's critical consensus reads, "You're the Worst continues to chart serious territory with intelligence, heart, and noxious wit in its third season, even as the anti-rom-com's damaged narcissist protagonists slowly start to get over themselves.

The site's critical consensus reads, "You're the Worst remains smartly idiosyncratic in its fourth season, deftly balancing its dramatic elements against some of the sharpest laughs on television.

The site's critical consensus reads, "Endearingly acerbic, You're the Worst refuses to overstay its welcome, delivering its fifth and final season with plenty of on brand care and cringe.