The film stars Kristen Bell, Jamie Lee Curtis, Sigourney Weaver, Odette Yustman, James Wolk, Victor Garber, Billy Unger, Kyle Bornheimer, Kristin Chenoweth, and Betty White in her final live-action film acting role before her death in 2021.

Her protective brother, Will, is a basketball star, oblivious to J.J.'s tormenting and her costing the team's crucial win by pushing the mascot-clad Marni into him.

Eight years later, Marni is a successful public relations executive in Los Angeles, recently promoted to their New York City office.

Marni and Will's mother Gail unhappily discovers that Joanna's beloved aunt Ramona, a wealthy businesswoman paying for the wedding, is her ex high school best friend.

Marni decides to save Will from J.J., and digs up a video from the time capsule buried during her senior year which shows Joanna's bullying.

When the guests make their toasts, an emotional Tim embarrasses Joanna by announcing she'd left him at the altar.

Later, the time capsule video is shown, with Joanna tormenting Marni and other students, including at the big basketball game.

The rivalry between the two grandmothers, Betty White and Cloris Leachman, is a reference to the conflict between the two on The Mary Tyler Moore Show.

The critical consensus reads: "You Again represents a rare opportunity to see some of Hollywood's finest female veterans together onscreen – and, unfortunately, wastes their talents almost completely.

The New York Times critic Stephen Holden wrote that "There is not a laugh to be found in this rancid, misogynistic revenge comedy," declaring "Like so many Disney movies, 'You Again' exalts shallow, materialistic values, then tries to camouflage its essentially poisonous content with several layers of sugar coating and weepy reconciliation.

[8] Among the more favorable reviews was Lana Berkowitz of The San Francisco Chronicle, who wrote that she enjoyed the mix of slapstick, musical numbers and surprise cameo appearances.

[2] The film was released by Touchstone Home Entertainment in a two-disc Blu-ray and DVD combo pack on February 8, 2011.