Phantogram began teasing a new single for their third studio album, Three, on their website in May 2016, posting a black and white clip of Sarah Barthel singing the lyrics of the new song.

[4] The title of single was revealed to be "You Don't Get Me High Anymore", with a countdown clock indicating that the song would be released on June 16, 2016.

[5] Josh Carter stated that the song is about, "the loneliness in superficial relationships and that feeling of not being able to find happiness in places that were once so easy to come across.

Above this, Sarah Barthel tunefully ruminates on teeth-shedding dreams, not being a homebody and taking note that certain parts of her life aren't as potent as they once were.

"[15] Katie Bain of Billboard stated, "The track oscillates between a throttling guitar riff evocative of Muse and lyrics about car crashes, staring into the abyss and increased chemical intake.

"[8] "You Don't Get Me High Anymore" debuted on the US Hot Rock & Alternative Songs chart at number 27 on the week of July 9, 2016.

[20] In October 2016, Canadian punk rock band PUP performed a cover of the track on Triple J radio in Australia.

"[23] In 2019, American singer-songwriter Billie Eilish performed a cover of the song for BBC Radio 1 at Maida Vale Studios.

"[27] The video combines visual scenes of gigantic waves, motorbike stunts, BDSM and saturated colourscape of red and blue.