In 1992, "Weird Al" Yankovic parodied the song on his Off the Deep End album as "The White Stuff", a loving ode to the cream filling in Oreo cookies.

Kid Rock, on his album The Polyfuze Method, sampled the song on his "Killin' Brain Cells".

In the season 8 episode of It's Always Sunny in Philadelphia "Charlie's Mom Has Cancer", Dr. Jinx (Sean Combs) plays the song on his electric bass to help Dennis have feelings again.

In the 2012 Adam Sandler comedy film That's My Boy, the character Todd Peterson (Andy Samberg) receives a tattoo of New Kids on the Block on his back as a child, which later becomes warped as he grows up.

In the first episode of Fuller House, DJ, Stephenie, Kimmy, and the rest of the cast dance to a 30-second clip of the song.

It is sung in the film by Eric Andre and Daveed Diggs, playing as their characters John Dory and Spruce.

The all-female singing group Fifth Harmony performed this song on the October 28, 2014, episode of the MTV series Faking It.