In the episode, Kyle Broflovski, Eric Cartman and Kenny McCormick make Stan Marsh a profile on the social networking service Facebook against his wishes, and he becomes extremely frustrated with everyone asking him for friend requests.

The episode also parodies the CNBC series Mad Money, as well as the online chat website Chatroulette, and the social network game FarmVille.

"You Have 0 Friends" has received positive reviews from critics, and according to Nielsen Media Research, the episode was viewed by 3.071 million viewers and became the cable lead in the 18–49 Wednesday night.

Kyle Broflovski, Eric Cartman and Kenny McCormick surprise Stan Marsh by creating a Facebook account for him.

To his annoyance and frustration, Stan finds people such as his father Randy, his grandmother, and even his girlfriend Wendy Testaburger confronting him over his supposed disregard for them and judging his friendship solely by his Facebook configuration.

This made it the second most viewed cable show of the night after In Plain Sight and attracting more viewers than the previous episode, "Medicinal Fried Chicken".

The episode also received an 18–49 rating of 1.7 and a share of 5% edging out Tyler Perry's House of Payne for the cable lead in the demographic.

"[7] Tucker of Entertainment Weekly said "The half-hour was shrewdly precise in its targets: The older audience that communes on Facebook (such as parents and grandparents) as well as lonely kids; as usual, "South Park" is merciless when it smells a baby-boomer-adopted trend.

"[4] Carlos Delgado of iF Magazine wrote that "You have 0 Friends has the right amount of humor, intelligence, and sarcasm to match any South Park episode.

"[8] Cristina Everett of the New York Daily News called the episode "hilarious, yet heartwarming", adding that the Kip Drordy subplot was "endearing".