It was released in the United Kingdom on 21 September 2009 and in Germany, Austria and Switzerland on 3 May 2010.

David Balls of entertainment website Digital Spy gave the song four out of five stars writing, "With its wistful chorus and cool-but-insistent beats, it's an affecting slice of break-up disco given a frisson of distinction by some authentically Chilean pan pipe flourishes [...] this has all the right ingredients to become a very big hit.

"[2] Fraser McAlpine of BBC Chart Blog gave the song a positive review stating, "There's some standard synthing in the background, which creates a lovely air of isolation, with Medina's haunting vocals on the top telling the story of a love gone wrong.

[...] it's perhaps not groundbreaking in any big way, since you've probably heard a variation on the general theme of this song millions of times before, but this one is well-crafted enough to be counted among the better examples.

On 20 May 2010 she performed "You and I" on the 54th episode of the German television music show The Dome in Stuttgart.