Series star Penn Badgley returns as Joe Goldberg and Tati Gabrielle reprises her role as Marienne Bellamy, with Charlotte Ritchie, Tilly Keeper, Amy-Leigh Hickman, Ed Speleers and Lukas Gage joining the main cast.

[2] The season is primarily set in London,[3] the first time outside the United States, and showrunner Sera Gamble said protagonist Joe Goldberg is "great when he's in an environment that's not natural to him, that's foreign to him".

[10] In April 2022, Tilly Keeper, Amy-Leigh Hickman, and Ed Speleers were cast as new series regulars, with Gabrielle confirmed to be returning as a regular, while Niccy Lin, Aidan Cheng, Stephen Hagan, Ben Wiggins, Eve Austin, Ozioma Whenu, Dario Coates, Sean Pertwee, Brad Alexander, Alison Pargeter and Adam James joined the cast in recurring roles for the fourth season.

[11] Jenna Ortega had been offered to reprise her role of Ellie Alves from the second season, but declined due to scheduling conflicts with the TV series Wednesday.

The website's critics consensus reads, "The hunter becomes prey in You's London-set fourth season, which shows some wear as this premise begins to outlive its believability—but Penn Badgley's sardonic performance continues to paper over most lapses in logic.