It was featured in the season finale of the CBS show Moonlight titled "Mortal Cure".

According to Ronnie Winter, the song is dedicated to the eight students that lost their lives in the March 1, 2007 tornado that destroyed a high school in Enterprise, Alabama.

The album version has 90 seconds of silence at the end, which leads into the unlisted 12th track; "The Grim Goodbye".

The music video for "Your Guardian Angel" shows Ronnie Winter turning on many lightbulbs, and singing the song in a closet with one light bulb, then he plays and sings while the band is preparing for a concert.

They perform in front of the crowd of fans with flashy light effects during the distortion part.