A 12-episode anime television series adaptation, produced by Nomad, was broadcast from October to December 2008.

A three-episode original video animation (OVA) series was released between October 2010 and November 2011.

A second 13-episode anime television series, titled Yozakura Quartet: Hana no Uta, was broadcast from October 2013 to January 2014.

Another three-episode OVA series, titled Yozakura Quartet: Tsuki ni Naku, was released from October 2013 to November 2014.

The story revolves around four teenagers; Hime, Akina, Ao, and Kotoha; each of them having their own unique abilities.

[6] Only five volumes were released from February 26, 2008,[7] to September 29, 2009,[8] before Del Rey Manga's closure in 2010.

The anime has been licensed in North America by Sentai Filmworks and is distributed by Section23 Films.

!, was included with the first Blu-ray/DVD volume of the Yozakura Quartet: Hana no Uta anime series, released on December 18, 2013.