[4] Ysbyty Ifan was on the ancient pilgrimage routes, for example, from Bangor Is Coed (Bangor-on-Dee) to Holyhead and Bardsey Island and the Cistercian Way between Aberconwy and Cymer.

[5][6] It is centrally located among a significant number of important pilgrimage destinations of the Middle Ages, see the map which shows only some of them.

In the 15th century, the Red Bandits of Mawddwy used Ysbyty Ifan as a hideout, taking advantage of the Knights' privilege of sanctuary.

1485–1510), a local nobleman who served Henry VII at the Battle of Bosworth, his wife Lowri, and his son Robert, chaplain to Cardinal Wolsey.

[5][6] There is a bridge over the Afon Conwy in the centre of the village Ysbyty Ifan has a primary school with two classrooms and a cafeteria.