She is a multi-instrumentalist (mainly piano, synthesizer, sampler and other keyboards), composer, record producer, and co-founder of the band Cibo Matto.

[1][2] Throughout her career, she has collaborated with a diverse array of musicians, including Petra Haden, Sean Lennon, Mike Watt, Nels Cline, Tricky, Harper Simon, Beastie Boys, Los Lobos, Brooklyn Funk Essentials, Mitchell Froom, Medeski Martin & Wood, Marc Ribot, Yoshimi P-We, Arto Lindsay, Edie Brickell, Vincent Gallo, Luscious Jackson, Dave Douglas, Bernie Worrell, and Caetano Veloso.

In 1992, she played Queen Elizabeth Hall in South Bank, London, supporting Arto Lindsay along with Marc Ribot, Bernie Worrell, and Brian Eno.

That year they met Russell Simins when they opened for Blues Explosion, and started the band Butter 08 with Mike Mills, Evan Bernard, and Rick Lee.

The two met when Honda remixed Yoko Ono's song "Talking to the Universe" (from the album Rising), along with Thurston Moore, Tricky, Beastie Boys and Ween.

Also in 1996, Cibo Matto worked with the film director Michel Gondry on their single Sugar Water, a highly artistic music video in the form of a visual palindrome.

In 2011, following an eight-year collaboration with Petra Haden, she produced and performed on the album "Salt on Sea Glass"[4] as a member of If By Yes, a group also consisting of Yuko Araki on drums and Hirotaka "Shimmy" Shimizu on guitar, with contributions from David Byrne and Nels Cline.

Since 2011 Honda has re-collaborated with Hatori for new Cibo Matto material, to culminate in 2014 with the release of the group's first album in 15 years, Hotel Valentine.