Yuma Crossing is a site in Arizona and California that is significant for its association with transportation and communication across the Colorado River.

It connected New Spain and Las Californias in the Spanish Colonial period in[2] and also during the Western expansion of the United States.

It was not until after the 17th and 18th century explorations of the padres Kino and Garcés that the crossing came to be used by the Spanish expeditions of Juan Bautista de Anza and others along this route from 1774.

At about the same time, the Butterfield Stage established a stagecoach station here for their main line coming from the east to California.

At Yuma Crossing, the stakeholders are particularly diverse, including Indian tribes, agricultural interests, environmental and wildlife non-profit organizations, as well as many federal, states, and local agencies.

In 2004, heritage area partners secured a Clean Water Act permit from the U.S. Army Corps of Engineers to begin restoration work.