He made his acting debut in the crime drama Elena (2011) and then won a Golden Eagle Award for his portrayal of Mikhail Kalashnikov in the biopic AK-47 (2020).

In 2014 he graduated from the Shchepkin Higher Theater School, and won the Golden Leaf award in the Best Actor category for the role of Alexander Tarasovich Ametistov in the play Zoyka's Apartment.

Borisov started working as a film actor in 2010, and played main roles in various television series.

In 2021 Borisov played the lead role in Juho Kuosmanen's Finnish-Russian film Compartment No.

In 2024, Borisov voiced Behemoth the Cat in The Master and Margarita, and played Igor in the Palme d'Or winning film Anora, directed by Sean Baker.