His father, Mikhail Nikolayevich Neprintsev was an architect, a Honored Art Worker of Science and Technology of the Georgian SSR (1946).

In 1929, Neprintsev began to work as designer and graphic artist in the palace-museums of Leningrad and the Pushkin town.

He studied of Pavel Naumov, Alexander Lubimov, and Isaak Brodsky, who 30 years ago was also a student of Vasily Savinsky.

Yuri Neprintsev worked in oil painting, pencil drawings, watercolors and book illustration.

After graduation, Neprintsev continued his education in postgraduate institute under leadership of Prof. Rudolf Frentz and Prof. Boris Ioganson.

In the postwar years, Neprintsev created a series of paintings devoted to the heroic struggle of the Soviet people against Nazi Germany: "The Last Grenade" (1948), "Lisa Chaikina" (1949), "The Rest After Battle" (1951), "The Story of the Father" (1955).

He was professor of painting (1954–1996), a head of personal workshop and graphical department of Repin Institute of Arts.