[10] Lutsenko has been a long serving people's deputy in the Verkhovna Rada (the Ukrainian parliament); first elected in 2002 and reelected in 2007 and 2014.

[14][15][16] In 2010, Lutsenko was charged with abuse of office and forgery by Prosecutor General of Ukraine Viktor Pshonka,[17] in what was widely viewed as political retaliation for having investigated one of Yanukovych's cabinet members four years earlier.

[10] On 5 July 2023 Lutsenko announced that he would no longer serve in the Ukrainian Armed Forces due to an established disability.

[25] In the September 2007 Ukrainian parliamentary election Lutsenko was reelected to the Verkhovna Rada as the number 1 on the list of the Our Ukraine–People's Self-Defense Bloc as a non-party member.

[26] On 15 May 2009, the Verkhovna Rada[c] passed a resolution, stipulating to address the government with a request to suspend Yuriy Lutsenko from the post of the Interior Minister of Ukraine until the "drunken incident" is investigated.

[33] President Viktor Yushchenko considered his appeal for resignation "a logical step, which should be made ..."[e] Prime Minister Yulia Tymoshenko believed that the information about the incident was doubtful.

[44][45] On 13 December 2010, Lutsenko was charged with abuse of office and forgery by Prosecutor General of Ukraine Viktor Pshonka.

[17] On 5 November, it was already announced that Lutsenko faced criminal charges for an alleged financial crime involving a less than $5,000 overpayment to his driver.

[48] Lutsenko was also charged with having signed an order whilst on holiday and not having cancelled the traditional "National Militia Day" despite a general instruction from the then Prime Minister to make budgetary savings where possible.

[53][54] Lutsenko filed a complaint in a U.S. court on 14 December 2011 against his (Ukrainian) prosecutors, made possible by the Alien Tort Statute, for "illegal arrest and arbitrarily prolonged detention".

[55] On 27 February 2012, after a pre-trial detention of 14 months,[56] Lutsenko was sentenced to fours year in jail (with confiscation of his property) for embezzlement and abuse of office.

[79] Lutkovska asked to pardon Lutsenko "due to the European standards of human rights, which include providing effective medical care to persons detained in prisons".

[80] On 7 April 2013, a decree by Yanukovych pardoned Lutsenko (among others) for health reasons and "to decriminalize and humanize Ukrainian legislation"[79] and the same day he was released from prison.

[81] Lutsenko and his family had repeatedly stated that they would not seek a pardon, because they believe the charges where groundless and political punishment.

[82] On 8 April 2013, the European Union welcomed the pardons of Lutsenko and Filipchuk, and urged Ukraine to continue addressing "the cases of selective justice".

[85][86] Lutsenko was hospitalised on 11 January 2014 in an intensive care ward after being beaten by police in protests following the sentence of verdicts in the 2011 Vasylkiv terror plot.

[14] In the 2014 Ukrainian parliamentary election, Lutsenko was re-elected into the Verkhovna Rada after being in the top 10 of the electoral list of Petro Poroshenko Bloc.

[96] Davis Manafort International in Kyiv had been accused of money laundering by Robert Mueller's Special Counsel investigation.

[96] Revealed in 2016 by Serhiy Leshchenko, who gave the records to the National Anti-Corruption Bureau,[101][102][h] the secret bookkeeping of Viktor Yanukovych and the Party of Regions' Black Ledger or Barn Book involved another investigation into Manafort in which the handwritten records of 22 payments to Manafort, nine of which had been signed by Vitaly Kalyuzhny who was the Verkhovna Rada's foreign relations committee chairman.

[100] After Ukrainian politician and activist Kateryna Handziuk died from complications from an acid attack on 4 November 2018, human rights organisations and NGOs demanded the resignation of Lutsenko and Interior Minister Arsen Avakov.

[108] Documents, provided by Lev Parnas to the U.S. House Intelligence Committee, outlined text exchanges in which Lutsenko pushed for the ouster of then U.S.

Ambassador to Ukraine Marie Yovanovitch and offered information related to former U.S. Vice President Joe Biden in return.

[111] Following the 2019 Ukrainian parliamentary election, Lutsenko was dismissed by the Verkhovna Rada on 29 August 2019, and replaced by Ruslan Riaboshapka.

[100] In April 2022, 2 months after the beginning of the 2022 Russian invasion of Ukraine, Lutsenko joined the Territorial Defence Battalion (of the Ukrainian Armed Forces) of Mykolaiv.

[10] On 20 February 2023 Commander-in-Chief of the Armed Forces of Ukraine Valerii Zaluzhnyi appointed Lutsenko as the commander of an unmanned aerial vehicle (UAV) platoon.

[9] On 5 July 2023 Lutsenko announced that he would no longer serve in the Ukrainian Armed Forces, as he was removed from conscription due to an established disability.

[115] In the 2014 Ukrainian parliamentary election, Iryna Lutsenko tried to get re-elected into parliament; this time by placing 70th on the electoral list of Petro Poroshenko Bloc.

[116][117] After fellow Petro Poroshenko Bloc members left the Verkhovna Rada, she returned as a People's Deputy on 27 January 2015.

[118] In the 2019 Ukrainian parliamentary election, she was re-elected for European Solidarity as 25th on the electoral list, but resigned in November 2019 for health reasons.