Zemio is a town and sub-prefecture in the Haut-Mbomou prefecture of the south-eastern Central African Republic.

[4] In 1924, a missionary named John Buyse established AIM mission station in Zemio.

[6] From 18 to 21 November 2014, a sectarian clash between Muslims and Christians ensued in Zemio, resulting in two people dead, two missing, and 15 injured.

[8] As of January 2021 Zemio remains under control of Union for Peace in the Central African Republic rebel groups.

[13] As of August 2023, Zemio is considered the most expensive city in Central African Republic.