The Zêzere (Portuguese pronunciation: [ˈzezɨɾɨ]) is a river in Portugal, tributary to the Tagus.

It rises in the Serra da Estrela, near the Torre, the highest point of continental Portugal.

The Zêzere runs through the town Manteigas, runs through Belmonte, passes south of the city of Covilhã and east of the town of Pedrogão Grande.

Its slope allows for the hydroelectric powerplants of Cabril, Bouçã and Castelo de Bode.

This article related to a river in Portugal is a stub.