Samedov has won multiple titles, most notably the K-1 World Grand Prix 2009 in Łódź tournament championship.

On August 17, 2007, following the K-1 World GP 2007 in Las Vegas event the Nevada State Athletic Commission (NSAC) issued a statement that Samedov tested positive for Stanozolol, an anabolic steroid.

[5] On 26 April 2008, Samedov competed in K-1 World Grand Prix 2008 in Amsterdam, dispatched Doug Viney and Brian Douwes respectively.

On November 29, 2008, Samedov faced Tyrone Spong for the inaugural It's Showtime 95MAX World title, and lost by unanimous decision.

[6] He faced Xavier Vigney at the K-1 World Grand Prix 2012 in Tokyo final 16 on October 14, 2012[7][8] and totally outclassed the young American, flooring him three times in the first round to win via TKO.

[11] However, Edwards withdrew due to having a fight booked with Paul Slowinski a week later, and was replaced by Badr Hari.

[13][14] Samedov scored a first round high kick KO over Wiesław Kwaśniewski at SUPERKOMBAT New Heroes 3 in Vienna, Austria on May 10, 2013.

[21][22][23][24][25] He competed in the -93 kg/205 lb tournament at Legend 2: Invasion in Moscow, Russia on November 9, 2013, taking a unanimous decision over Melvin Manhoef in the semi-finals.

[26][27][28] Returning to the ring for the first time in eight months, Samedov scored a 21-second high kick knockout over Stefan Leko on the undercard of the Ruslan Chagaev vs. Fres Oquendo boxing match in Grozny, Russia on July 6, 2014.

[43] Semedov made his comeback against Deji Kalejaiye, after a two and a half year hiatus, at the WTKF Belarus event.