Artists with whom they have collaborated include Alan Jackson, Angie Aparo, Jimmy Buffett, Kid Rock, Jason Mraz, Dave Grohl, Chris Cornell, Brandi Carlile, Avicii, Los Lonely Boys, Sara Barellies and John Fogerty of Creedence Clearwater Revival.

In 2004, Brown opened a music club and restaurant with his father in the Lake Oconee area of Georgia, called "Zac's Place" where the fare was southern-style cooking.

The two remained friends, and in 2005, Hopkins stepped in as bass guitarist while helping the group finish what became their number-one single "Toes".

[12] The Zac Brown Band's debut single, "Chicken Fried", was originally recorded in 2003 and included on the Home Grown album, but later re-recorded and released to country radio in 2008.

In the third episode of HBO's music documentary series Sonic Highways, Brown was a featured interviewee and explained why Lost Trailer's version of "Chicken Fried" was pulled from the radio.

Some months later the Lost Trailers landed a deal with Sony Nashville, and when they submitted the tracks for their album, they included "Chicken Fried".

Joe Galante, then the Chairman of Sony Music Nashville, heard the tracks and chose "Chicken Fried" as the single that the label wanted to promote.

Brown was insistent that his agreement with the Lost Trailers was violated, so his lawyer issued a cease and desist letter and the single was pulled from the radio.

The band's album The Foundation was released under Atlantic Records' newly re-established country division in association with the Home Grown/Bigger Picture label on November 18 of that year.

1, Atlanta native Clay Cook joined the Zac Brown Band as its multi-instrumentalist and high tenor vocalist.

De los Reyes had previously performed with the band as a touring musician and participated in the recording of their album Uncaged.

De los Reyes has also performed with artists and groups such as Earth, Wind and Fire, Jennifer Lopez and Sting.

The album's fourth single, "Sweet Annie", was released to country radio in August 2013, and rose to number 1 in January 2014.

In April 2014, the band announced its summer tour schedule, which included Kacey Musgraves as an opening act, and the addition of Matt Mangano as an eighth member.

The terms of the deal state that the Zac Brown Band will work with Big Machine Label Group for marketing and distribution, while Southern Ground Artists will work on radio promotion, Republic will provide support in the area of non-country radio formats and international promotion, and Varvatos will oversee branding and styling.

The song, co-produced by Jay Joyce, was the lead single to an album, titled Jekyll + Hyde, which was released on April 28, 2015.

Despite being a country album, Jekyll + Hyde features prominent styles from other genres in several of its tracks including rock (Heavy Is the Head),[25] EDM (Beautiful Drug),[25] celtic (Remedy),[26] reggae (Castaway)[26] and traditional pop/jazz (Mango Tree).

[29] On January 30, 2017, the band previewed cover art for a new album titled Welcome Home produced by Dave Cobb, was released on May 12, 2017.

[31] In September 2018, it was announced that Zac Brown Band would make their second appearance of CMT Crossroads along with Shawn Mendes, which was televised on October 24, 2018.

The album includes collaborations with Skrillex, Max Martin, Ryan Tedder, Benny Blanco, Andrew Watt, Jason "Poo Bear" Boyd, and others.

In Fall of 2009, the band began offering fan-club members the ability to purchase tickets to VIP Eat & Greet experiences before the majority of their tour appearances.

These events afford fans the opportunity to share a meal with band-members before the show, and have become an integral part of the overall Zac Brown Band live experience.

[80] In 2011, the Zac Brown Band and Blackberry Smoke held a concert tour at venues and amphitheaters including Hollywood Bowl in Los Angeles, CA.

[82] Zac Brown Band completed a three-night, headlining stint at Red Rocks Amphitheatre on Wednesday, May 8, 2013, Thursday, May 9, 2013, and Friday, May 10, 2013.

[86] On January 21, 2014, Zac Brown Band released a live version of their 2010 #1 hit "Free" (transitioning into the Van Morrison classic "Into the Mystic").

[89] The band has also supported Little Kids Rock, a national nonprofit that works to restore and revitalize music education programs in disadvantaged U.S. public schools, by donating items for auction to raise money for the organization.

[90] On January 16, 2013, Zac Brown, Clay Cook, and David Ryan Harris played a benefit with John Mayer for the firefighters and the residents of Pine Creek in Park County, Montana, who fought a fire that swept through the area, and destroyed five homes.