Zacatecoluca (Spanish pronunciation: [sakatekoˈluka]) is the capital municipality of the La Paz Department of El Salvador.

Located in Southern El Salvador, in the Rio Lempa valley, at the foot of San Vicente (Chinchotepec) Volcano.

A commercial center for the surrounding agricultural area, it also trades in cotton goods, baskets, salt, and lumber.

Zacatecoluca was the birthplace of José Simeón Cañas, who fought for and secured the emancipation of slaves in Central America by Spaniards in 1825.

Santa Lucia Catholic Church holds a dear history to the people of Zacatecoluca, as an image of Virgin Mary placed on top is said to have stopped an eruption of lava and ash from completely destroying the city and its local population.