He made his Major League Baseball (MLB) debut for the Dodgers in 2015 and also played for the San Diego Padres in 2017.

[1] Lee had committed to playing baseball and football[2] at Louisiana State University and enrolled in summer school.

He was considered a tough signing due to his football commitment and reportedly dropped in the draft as a result.

[7][failed verification] Lee made his debut in the Dodgers organization for the Great Lakes Loons in the Single–A Midwest League in 2011.

[1] Lee's 2011 performance led Baseball America to list him as the best prospect in the Dodgers farm system.

[10] His start with the Lookouts was slow, but Lee improved as the season went on thanks to mechanical adjustments in his pitching delivery.

[19] The problem was diagnosed as irritation due to poor circulation and he was put back on a throwing program.

[20] Prior to his major league debut, Lee had compiled a record of 7–3 and an ERA of 2.36 with Oklahoma City.

[28] He contended for the fifth starter spot on the major league club during spring training but was beat out by Ross Stripling and optioned back to Triple–A.

Mariners general manager Jerry Dipoto, a prolific trader, has referred to this as one he wishes he could take back[34] and that he "whiffed" on it.

[38] Lee led the Southern League with a 2.22 ERA with 64 innings pitched and was named to the Mid season All-Star team (he did not play).

[citation needed] He made 26 total appearances (25 starts) split between the Triple–A Durham Bulls and Double–A Montgomery Biscuits, accumulating a 12–6 record and 3.65 ERA with 107 strikeouts across 145+2⁄3 innings pitched.

[41] On November 25, 2019, Lee signed a minor league contract with the Oakland Athletics that included an invitation to spring training.

[44] On February 6, 2021, Lee signed a minor league contract with the Arizona Diamondbacks organization.