From 2009 to 2011 with the Jaguars, he started only five games with 33 appearances, followed by a brief stint with the Tampa Bay Buccaneers that also resulted in injury.

In 2015, Miller enjoyed a breakout season as he appeared in 16 games and recorded five touchdowns, but had further season-ending injuries in subsequent years.

The injury was severe and threatened potential leg amputation, but successful surgeries saved the limb.

[14] During the 2014 preseason, he recorded two touchdowns against the Philadelphia Eagles before sustaining a Lisfranc injury to his left foot in the following game.

[18] One week later, Miller caught five passes for 107 yards, including an 87-yard touchdown pass from Cutler, en route to a 37–13 win over the St. Louis Rams; the catch was the longest by a tight end since Byron Chamberlain's 88-yard play in 1999 and the longest touchdown reception by a Chicago Bear since Matt Forte's 89-yard rush in 2010.

[22] In the fourth game of 2017 against the Minnesota Vikings, Miller caught the first career touchdown pass of Bears second-overall draft pick Mitchell Trubisky.

[23] On the ensuing two-point conversion, the two were involved in a trick play to tie the game: Trubisky gave the ball to running back Jordan Howard on what appeared to be a draw play until Howard handed off to Miller, who was running in the opposite direction.

[24] The following week against the Baltimore Ravens, Miller was the recipient of running back Tarik Cohen's 20-yard touchdown pass on another trick play.

[25] On October 29, 2017, in the Bears' Week 8 game against the New Orleans Saints, Miller landed on his left knee while attempting to catch a touchdown pass, dislocating it.

[26] He was taken to nearby University Medical Center New Orleans where further examination revealed he not only dislocated his left knee, but also tore his popliteal artery, a serious, career-threatening injury that raised the possibility of amputation.

Referee Carl Cheffers defended the call, explaining Miller needed "to survive the ground" as he landed with the ball.

I didn't see anything definitive to overturn it and quite frankly, if it had been ruled incomplete on the field, if it had been me in the command center, I would have reversed it to a catch.

"[31] In a May 2018 interview, Saints head coach Sean Payton, who visited Miller in the hospital, argued the play should have been a score.

[32] The day after the game, Bears head coach John Fox announced he would send video of the play to the NFL.

It’s difficult to find the words to express my love and gratitude to every single person that has cheered my name, lifted me up and stood strong with me throughout my career.

He previously wrote songs for his family, and his interest in music grew while recovering from his leg injury.