Zach Robert Plesac (born January 21, 1995) is an American professional baseball pitcher who is a free agent.

[3] The Cleveland Indians selected Plesac in the 12th round, with the 362nd overall pick, of the 2016 Major League Baseball draft.

[5] In 2018, Plesac played for both the High-A Lynchburg Hillcats and the Double-A Akron RubberDucks, pitching to a combined 11–6 record with a 3.79 ERA in 26 total starts between both teams.

[7] He made his MLB debut that day at Fenway Park against the Boston Red Sox,[4] allowing one run on four hits in 5+1⁄3 innings and receiving a no decision.

In his first start of the 2020 season, Plesac had one of the best outings of his career against the Chicago White Sox, going eight innings, striking out 11, and allowing no earned runs.

[10] On August 9, Plesac was sent home by the Indians after violating team and Major League Baseball COVID-19 protocols after going out with friends in Chicago following a game against the White Sox.

[12] With the 2020 Cleveland Indians, Plesac appeared in eight games, compiling a 4–2 record with 2.28 ERA and 57 strikeouts in 55+1⁄3 innings pitched.

Plesac was the starting pitcher on the opposite end of three no-hitters, an MLB record; the Indians were the first team to be no-hit in three games in one season.

[15] On January 13, 2023, Plesac agreed to a one-year, $2.95 million contract with the Guardians, avoiding salary arbitration.