A wooden Catholic church dedicated to St. Marguerite was located on the place of the modern day cathedral in the 14th century.

[2] Duding the Josephinism period the state implemented significant reforms that affected life of religious communities.

By city government decision the old church was offered at auction and sold to the Zagreb Croatian Orthodox Parish for 4,000 florins.

[1] In 1848, during Revolutions of 1848, the Orthodox Parish added the suffix Serbian in its name since by that time the Serbs (under the autonomous Patriarchate of Karlovci) significantly outnumbered local Greeks and Aromanians.

[1] The iconostasis of the Orthodox Cathedral comprises a total of 34 icons and 4 free-standing walnut pillars.