Zakithi Nene (born 2 April 1998) is a South African sprinter, who specializes in the 400 metres.

He won the South African 400m national title in 2021 and qualified for the 2020 Summer Olympics through his world ranking.

[4] He competed at the 2024 Summer Olympics over 400 metres in August 2024, reaching the semi-finals.

[7] He studied economics at the University of KwaZulu-Natal in his native South Africa.

This biographical article relating to South African athletics is a stub.