Formed in 1991 during what was then billed as Ozzy Osbourne's farewell tour following the 1991 No More Tears album, Wylde recruited the former White Lion rhythm section of bassist James LoMenzo and drummer Greg D'Angelo, and originally wanted to name the Southern rock-inspired project 'Lynyrd Skynhead'.

On January 31, 1998, the lineup of Wylde, LoMenzo, and Tichy reunited for a one-off reunion show at the Whisky a Go Go in Hollywood.

Wylde wrote the second installment of Book of Shadows in between stints on the road, which was released 20 years after the first album on April 16, 2016.

[20] John DeServio, who was a friend of Zakk's[21] and worked as a temporary replacement in Pride & Glory, played bass for the first Black Label Society tour.

[23] Black Label Society headlined the second stage at the 2006 Ozzfest, with Wylde playing double duty with Ozzy Osbourne on certain dates.

[25] Since 2014, Wylde has led a Black Sabbath cover band called 'Zakk Sabbath', handling guitar and vocal duties, joined by Rob "Blasko" Nicholson on bass and Joey Castillo (Danzig, Queens of the Stone Age) on drums, who replaced original drummer John Tempesta.

[27] On July 14, 2022, it was announced that Wylde had joined the reunited band Pantera to tour as a fill-in for original guitarist Dimebag Darrell who died in 2004.

[28] The new line-up featuring Wylde, Phil Anselmo, Rex Brown and Charlie Benante (replacing original drummer Vinnie Paul) debuted on the first night of the Heaven & Hell Metal Fest in Toluca, Mexico on December 2, 2022.

[29] Pantera then co-headlined Mexico's Monterrey Metal Fest with Judas Priest,[30] and also performed at Knotfest in Chile, Brazil and Colombia.

[34] The group also includes guitarists Nuno Bettencourt (of Extreme), Yngwie Malmsteen, Tosin Abasi, and has completed several tours from 2016 to 2019.

[40] In August 2009, Wylde was hospitalized due to blood clots[41] and was subsequently forced to cancel his tour with Mudvayne and Static-X.

Metaltronix was building a one-off live rig for Wylde that was designed around one of the owner's guitars, a creamy white Les Paul Custom with EMG pickups, which would later become known as "The Grail".

[47] Wylde lost the guitar in 2000 after it fell from the back of a truck transporting equipment as he was travelling between gigs in Texas.

Originally created by luthier Karl Sandoval of California (used by Randy Rhoads), the guitar is often mistaken as a custom Flying V. Wylde has a custom Dean Splittail with a mud splatter bulls-eye graphic, as well as a signature Splittail shaped Gibson model called the "ZV".

Wylde has an extensive relationship with Marshall Amplification due to his love for their amplifiers, both solid state and tube-driven.

Live, Wylde exclusively uses Marshall JCM 800's with twin 4 X 12 Cabinets loaded with EVM12L 300W Black Label Speakers.

[51] In January 2006, Zakk Wylde was recognized at the Hollywood Rock Walk of Fame for his successful career as a musician and his contribution to the music industry.