He studied at Kfar Haroeh yeshiva high school, and was among the founders of Yeshivat Kerem B'Yavneh.

In 1988, Rabbi Melamed founded the Arutz Sheva radio station "to combat the 'negative thinking' and 'post-Zionist' attitudes so prevalent in Israel's liberal-left media".

[1] On halachic grounds, Rabbi Melamed opposes the idea of both Jews[4] and gentiles[5] visiting the Temple Mount.

Rabbi Melamed has stated that, "There must be legislation allowing Jewish people everywhere in the world to become Israeli citizens, even if they do not live here."

At the same time, he advocated that certain Arab citizens of Israel should be stripped of their citizenship: "Even those with a democratic viewpoint understand that we must limit the rights of those who wish to harm the State.