In 1988, Sydykova became working a reporter for the popular newspaper, Komsomolets Kirgizii, the local organ of the Soviet communist party's youth wing, Komsomol.

The always dangerous often lonely struggle of journalists like Zamira Sydykova belongs to anyone who believes that our destiny is tied to securing the basic human rights of people everywhere, whoever they are."[2].

After the Tulip Revolution overthrew Akayev, President Kurmanbek Bakiyev appointed Sydykova as Ambassador of the Kyrgyz Republic to the USA and Canada.

In addition, Sydykova kept Kyrgyzstan on the agenda for multilateral institutions, US Congress, the Canadian government, business organizations, and cultural groups.

[5] In addition, Sydykova served as Senior Advisor to Discovering Eurasia (where she worked on projects with Supreme Fuel and Theodore Willi Inc.),[6] and consultant to Hussar & Co. and Adilet.