The family was influential in Polish politics for several centuries, and its members held various official titles, including those of Count and Countess.
His sons Florian (died 1510) and Maciej assumed the name Zamoyski, and the family began to rise in prominence.
Florian’s grandson Stanisław was the castellan of Chełm, and his son, Jan Zamoyski, arguably the most famous member of the family, became a chancellor, hetman, and founded the Zamoyski's Ordynat - a large estate that was a major source of the family's wealth.
Brothers Andrzej Artur Zamoyski and Władysław Stanisław Zamoyski, supported Polish movements aimed at regaining independence during the partitions period; Władysław was exiled after participating in the November Uprising, and Andrzej, in the aftermath of the January Uprising.
Andrzej's grandson, Maurycy Zamoyski, was a Minister of Foreign Affairs in the Second Polish Republic for seven months in 1924.