Zayante Creek (Ohlone: Sayant) is a 10.3-mile-long (16.6 km) stream within the San Lorenzo River watershed in Santa Cruz County, California, United States.

The U.S. government has designated Zayante Creek as impaired with respect to sediment.

[4] In the period 1998 to 2000 a restoration project was conducted for this stream to improve anadromous fish passage, rearing and spawning.

[5] There has been a permanent U.S. Geological Survey gauging station on Zayante Creek which has operated since the year 1959; the mean altitude of the Zayante Basin, carved within the western slopes of the Santa Cruz Mountains, is 1,000 feet (300 m).

Several notable ecological features are present in the Zayante Creek watershed, including the occurrence of a rare forest type: maritime coast range ponderosa pine forest, which contains two endangered arthropods.